| Pair Name | Cantharidin, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Cantharidin (PubChem CID: 5944 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Cantharidin, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Down-regulation | Expression | CFLAR | hsa8837 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 |
| Result | The results of the present study revealed that cantharidin effectively sensitized cells to TRAIL‑mediated apoptosis and its effects are likely to be mediated by autophagy, the downregulation of c‑FLIP and the upregulation of DR‑5. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Downregulation of c‑FLIP and upregulation of DR‑5 by cantharidin sensitizes TRAIL‑mediated apoptosis in prostate cancer cells via autophagy flux. Int J Mol Med. 2020 Jul;46(1):280-288. doi: 10.3892/ijmm.2020.4566. | Click |
